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Osteonecrosis asociada al uso de bifosfonatos: A propósito de un caso clínico / Osteonecrosis associated with the use of biphosphonates: Case report

Anguita C., Timoleón; Agurto P., Jaime; Roa E., Iván; Laissle C., German.

Rev. méd. Chile ; 134(9): 1161-1165, sept. 2006. ilus

Article in Spanish, English | LILACS | ID: lil-438419

ABSTRACT

Biphosphonates reduce the risk of skeletal events and are currently part of standards of therapy in myeloma. Recently, zoledronate and pamidronate have been linked to osteonecrosis of the jaw, specially after surgical dental procedures. We report a 84 year-old man with multiple myeloma who developed spontaneous osteonecrosis of both jaws, after 36 months of therapy with zoledronate with a cumulative dose of 136 mg. We discuss the pathogenic mechanisms, and review the recommendations on prevention and management of this new complication for neoplastic patients under prolonged therapy with biphosphonates.

Subject(s)

Aged, 80 and over , Humans , Male , Bone Density Conservation Agents/adverse effects , Diphosphonates/adverse effects , Imidazoles/adverse effects , Jaw Diseases/chemically induced , Multiple Myeloma/drug therapy , Osteonecrosis/chemically induced , Jaw Diseases/pathology , Osteonecrosis/pathology

Aspectos de la respuesta inmunológica a infecciones en pacientes oncohematológicos / Aspects of immunological response to infections in oncohematological patients

Anguita C., Timoleón.

In. Osorio Solís, Guido. Hematología: diagnóstico y terapéutica. Santiago de Chile, Mediterráneo, 2 ed; 1997. p.481-4, tab.

Monography in Spanish | LILACS | ID: lil-209012

Subject(s)

Humans , Communicable Diseases/immunology , Hematologic Neoplasms/immunology , Communicable Diseases/complications , Hematologic Neoplasms/complications , Immunocompromised Host , Immune System/drug effects

Síndrome uña-rótula asociado a gammopatía monoclonal: revisión a propósito de un caso / Nail patella syndrome associated to monoclonal gammopathy

Panace V., Rita; Mocarquer Mocarquer, Alfredo; Anguita C., Timoleón; Cortés H., Hugo.

Rev. méd. Chile ; 121(1): 59-64, ene. 1993. ilus

Article in Spanish | LILACS | ID: lil-116793

Subject(s)

Humans , Female , Middle Aged , Monoclonal Gammopathy of Undetermined Significance/complications , Nail-Patella Syndrome/physiopathology , Nail-Patella Syndrome/diagnosis

Plasmaféresis en pancreatitis aguda secundaria a hiperlipidemia familiar en una embarazada / Plasapheresis in acute pancreatitis secondary to familial hyperlipidemia in a pregnant woman

Majlis D., Sergio; Anguita C., Timoleón; Weishaupt A., Ricardo; Socías G., Miguel.

Rev. méd. Chile ; 117(11): 1275-8, nov. 1989. tab, ilus

Article in Spanish | LILACS | ID: lil-82468

Subject(s)

Pregnancy , Adult , Humans , Female , Pancreatitis/therapy , Plasmapheresis , Hyperlipidemia, Familial Combined/complications , Pregnancy Complications/therapy , Pancreatitis/diagnosis , Pancreatitis/etiology , Enteral Nutrition , Parenteral Nutrition , Acute Disease

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